摘要
目的 探讨广东汉族群体HLA抗原多态性分布的情况。方法 随机选择了 1 0 6例广东籍汉族人进行HLA分型。分别采用微量淋巴细胞毒试验及PCR -SSP方法检测了HLAⅠ类A ,B位点及HLAⅡ类DR位点。结果 共检出了HLA -A位点抗原 1 0种 ,HLA -B位点抗原 2 1种 ,HLA -DR位点抗原 1 3种 ,并与北方人群抗原分布进行对比。结论 A1 1 ,B46和B6 0抗原频率比北方人群有显著增高 ,而A1 ,A3,B7等抗原则相对减少 ,显示广东地区汉族人群与北方人群间在HLA多态性分布上有较显著的差异。
Objective To study the polymorphism of HLA antigen in Guangdong Han nationality. Methods 106 persons living in Guangdong province were randomly selected and HLA-A, B and DR typing were measured by microdroplet lymphcytotoxicity test and PCR-SSP. Results 10 HLA-A, 21 HLA-B and 13 HLA-DR antigens were detected. Compared with Han nationality in northern China, the frequency of antigen A11, B46 and B60 in Guangdong Han was higher than that of North Han nationality, but HLA-A1, A3 and B7 antigens were less common. Conclusion There is obvious difference in polymorphism of HLA antigen between Guangdong Han and North Han nationality.
出处
《广东医学》
CAS
CSCD
2001年第8期662-664,共3页
Guangdong Medical Journal
基金
美国中华医学基金资助项目 (编号 :96630 )
