摘要
目的 :探讨冬凌草甲素的抗突变作用。方法 :用大鼠肺及肝原代细胞非程序DNA合成 (UnscheduledDNASynthesis,UDS)实验检测冬凌草甲素对UDS的影响。结果 :冬凌草甲素可明显地抑制诱变剂诱导的UDS水平 ,尤其是对盐酸氮芥 (NH2 ·HCl)诱导肝原代细胞UDS的抑制作用更为明显 (P <0 .0 1) ,其抑制率达 73 8%。结论
Aim: To probe the antimutagenicity of Oridonin.Methods: The effect of Oridonin on Unscheduled DNA Synthesis (UDS) was studied with UDS assay in primary cells of the lung and liver in rat. Results: Oridonin could inhibit UDS which was induced by mutagen.The Oridonin's inhibition of UDS induced by NH 2·HCl in primary cells of liver was particularly significant ( P <0.01),and the inhibition rate was 73.8%.Conclusion:Oridonin has significant antimutagenic effect
出处
《河南医科大学学报》
北大核心
2001年第4期415-416,共2页
Journal of Henan Medical University
基金
国家自然科学基金资助项目 3970 0 178
