摘要
目的 探讨蓝光发光二极管 (lightemittingdiodes ,LEDs)对新生儿高胆红素血症的光疗效应。方法 将LEDs与普通蓝光灯分成四组 :LEDs组、单面蓝光组、LEDs +单面蓝光组、双面蓝光组。四组光源照射黄疸早产儿 ,然后应用高效液相色谱仪 (HPLC)测定血、尿中胆红素光异构体的变化 ,同时观察皮疹、体温、大便性状等改变情况 ,评价LEDs的效应。结果 黄疸早产儿分别在四组光源照射 6h后 ,血清胆红素构象异构体 (14Z ,15E bilirubinⅨα,ZE)和胆红素结构异构体 (lumirubin ,LR)的含量LEDs组 [(13 0± 1 9)、(3 9± 1 0 ) μmol/L]与单面蓝光组 [(13 4± 2 2 )、(4 3± 1 2 ) μmol/L]比较差异无显著性 (P >0 0 5 ) ;LEDs +单面蓝光组 [(2 1 9± 2 3)、(7 2± 1 4) μmol/L]与双面蓝光组[(2 3 1± 3 3)、(7 5± 1 4) μmol/L]比较差异无显著性 (P >0 0 5 ) ;而LEDs +单面蓝光组、双面蓝光组均大于LEDs组和单面蓝光组 (P <0 0 5 )。在光照 12h后血清ZE的量及 12h内尿LR的总排出量四组比较 ;LEDs+单面蓝光组、双面蓝光组均明显大于LEDs组、单面蓝光组 (P <0 0 1)。光组 12h后血清LR的量 ,四组比较差异无显著性 (P >0 0 5 )。LEDs光照新生儿未发现皮疹、腹泻及发热 ,而普通蓝光光照新生儿有个别出现发热和?
Objective Jaundice is a common neonatal syndrome. The most widely used treatment is phototherapy. While the most of light sources used presently works with the short coming of heat production. In this study the authors evaluated the effects of a novel type of light source, the blue light emitting diodes (LEDs) on phototherapy for neonatal hyperbilirubinemia, which is a narrow spectral band, high intensity monochromatic and minimal heat producing light source.Methods Eighty seven jaundiced premature infants were irradiated by four light sources, including LEDs, single side conventional blue light (sCBL), LEDs+sCBL, and double side conventional blue light (dCBL). For estimating the effects of these four light sources, the quantity of serum and urinary bilirubin isomers were detected before and during phototherapy with high performance liquid chromatography (HPLC). In the meanwhile the side effects of phototherapy, such as rash, loose stool and temperature instability were also observed. Results The amounts of serum 14Z, 15 E bilirubin Ⅸα (ZE) and Lumirubin (LR) in LEDs group after 6 h of phototherapy were 13.0±1.9 and 3.94±1.0 μmol/L respectively, which were the same as those in sCBL group (13.4±2.2 and 4.3±1.2 μmol/L respectively) ( P >0 05). No significant difference was found between LEDs+sCBL group (21.9±2.3 and 7.2±1.3 μmol/L respectively) and dCBL group (23.1±3 3 and 7.5±1.4 μmol/L, respectively) ( P >0 05). There were significant difference between the LEDs group or the sCBL group and the LEDs+sCBL group or the dCBL group ( P <0 01); so were the serum ZE after 12 h of phototherapy and total urinary LR excretion during that period ( P <0 01 respectively). There was no significant difference in the serum LR level within four groups after 12 h of phototherapy. The side effect of LEDs phototherapy was minimal. Conclusions The determination of serous and urinary bilirubin isomers quantitatively could be applied to estimate the efficacy of phototherapy with different light sources. The analysis of urine LR with HPLC during phototherapy might be a non invasive and much better option. The efficacy of LEDs was the same as sCBL. LEDs can be installed in the incubator underpan for phototherapy, and exhibited with characteristics of the safety and minimal side effect during the phototherapy for premature newborns.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
2001年第6期323-326,共4页
Chinese Journal of Pediatrics
