摘要
本文采用巨噬细胞吞噬率(免疫荧光快速测定法)为检测指标,结合人血单核细胞体外实验和小鼠腹腔巨噬细胞整体染毒实验,从免疫毒理学角度探讨了奶牛、猪和鸡粪水溶性提取物的危害。结果表明,三种动物均能抑制人血单核细胞的吞噬功能。并有明显的剂量-反应关系。三种粪便对单核细胞的抑制能力极为相似。经10天猪粪水溶性提取物连续灌胃染毒的小鼠腹腔巨噬细胞实验也获得与体外实验相似的结果。
In this paper, the macrophages phagocytosis function impaired by thefecal extracts of domestic animals were reported. The results showed thatthe fecal extracts of cow, pig, and chicken might significantly inhibitthe phagocytosis function of human blood monocytes and had a good dose-response relationship between the phagocytosis function and exposuredoses in vitro assay. Furthermore, a similar result was obtained frommice in vivo assay, the phagocytic rate of the abdominal macrophageswas decreased after oral administration of pig fecal extract, the rate wasequivalent to 61.3±7.4; 33.7±4.6; 28.4±5.7% in correspondance with thedoses 0, 0.024, 0.048 gram dry fecal extract/gram body weight administ-rated continually for 10 days.
出处
《解放军预防医学杂志》
CAS
北大核心
1991年第2期96-99,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
关键词
粪提取物
家畜
吞噬作用
巨噬细胞
fecal extract
domestic amimals
phagocytosis
macrophages
