摘要
目的：了解硝酸酯类药物对中心动脉压的影响。 方法：５２例行左心导管术患者，平均年龄（５３．３±１０．８）岁。其中冠心病３２例，合并高血压和（或）糖尿病１８例；原发性高血压６例；其它１４例。晨起停服心血管药物，在冠状动脉造影或射频导管消融术（左心室旁道）后，用导管直接测定升主动脉压，并记录血压波形；同时用袖带汞柱血压计测定右臂肱动脉压，连续测定２次，取均值。其中３３例舌下含化硝酸异山梨酯１０ ｍｇ；１９例舌下含化硝酸异山梨酯５ ｍｇ后１０分重复上述操作。 结果：舌下含化硝酸异山梨酯１０ ｍｇ或５ ｍｇ后升主动脉收缩压下降均较肱动脉明显，而舒张压变化不大。用药前后升主动脉收缩压差值与升主动脉脉压虽无显著相关，但相关系数为０．２０２６． 结论：硝酸酯类药物有降低动脉收缩压的作用，且降低中心动脉收缩压的作用明显大于肱动脉收缩压。
Objective:To evaluate the effect of ni trates on central aortic pressure. Methods:Left-heart cannulation was used in 52 patients,aged 53.3±10.8 years,inclu ding 32 with coronary artery disease,18 w ith hypertension and/or diabetes;6 with hypertension;14 with other diseases.Card iovascular medications were all disconti nued in that morning.After coronary arte riography or radiofrequency catheter abl ation(left accessory pathway),ascending aortic pressures were measured with cathe ters,and their pressure waves were recor ded.In the meantime,the right brachial p ressure was measured by the cuff method of auscultation.Sublingu al isosorbide dinitrate 5 mg was given t o 19 patients and 10 mg to 33 patients.A fter 10 minutes,repeated the above proce ss. Results:After medication,the central aor tic systolic pressure was decreased more significantly than that of brachial ar tery,diastolic pressure no change.The cen tral aortic systolic pressure decreasing was no relative to its pulse pressure,b ut the relative coefficient was 0.2026. Conclusions:Nitrates may decrease the central aortic systolic pressue,and more significantly than that of the brachial artery.
出处
《中国循环杂志》
CSCD
北大核心
2001年第4期292-293,共2页
Chinese Circulation Journal
