摘要
目的：通过测定血清肺炎衣原体（ＴＷＡＲ）ＩｇＧ、ＩｇＭ抗体滴度水平，探讨肺炎衣原体感染与冠心病的相关性。 方法：应用间接微量免疫荧光法，测定１１５例冠心病病人（冠心病组）和６０例健康人（正常对照组）血清肺炎衣原体ＩｇＧ、ＩｇＭ抗体滴度。 结果：冠心病组病人血清肺炎衣原体ＩｇＧ平均几何滴度（ＧＭＴ）（１∶５７．７７±４．４２）与正常对照组（１∶１９．９３±４．２９）相比有非常显著性差异（Ｐ＜０．００１）。冠心病组肺炎衣原体既往感染阳性率明显高于正常对照组（７０．４％ｖｓ ３６．７％，Ｐ＜０．００１），２组急性感染阳性率无明显差异（Ｐ＞０．０５）。随着肺炎衣原体ＩｇＧ抗体水平（ＩｇＧ≥１∶１６）的增高，发生冠心病风险相对增高（ＯＲ ４．３６，９５％ＣＩ ２．３２～８．１６）。不稳定性心绞痛病人、急性心肌梗塞病人血清肺炎衣原体ＩｇＧ平均几何滴度及感染阳性率均无明显差别，但两者与正常对照组相比均有非常显著性差异（Ｐ＜０．００１）。 结论：研究结果表明，冠心病组病人肺炎衣原体感染率及血清肺炎衣原体ＩｇＧ平均几何滴度均较高，有抗体者（ＩｇＧ≥１∶１６）发生冠心病的风险相对增加，肺炎衣原体感染可能是构成?
Objective:To evaluate the association between chlamydia pneumoniae infection and coronary heart disease. Methods:TWAR IgG,IgM antibodies were measured by microimmuno fluorescence test on admission in 115 patients with coronary heart disease(CHD)and 60 subjects without CHD. Results:Geometric mean IgG titre(IgG GMT)was significantly higher in patients with CHD(1:57.77±4.42,p<0.001)compared with the controls(1:19.93±4.29,p<0.001).The frepuency of chronic infection was sig nificantly higher in CHD group than in the controls (70.4% vs.36.7%,p<0.001).No significant difference of acute infection(p>0.05)was found between both groups.Higher TWAR IgG antibody titres(IgG≥1:16)were associated with increased risk of CHD(OR 4.36,95% CI 2.32-8.16) Conclusions:There are higher chronic Chlamydia pneumoniae infection rate and TWAR IgG GMT in CHD.Higher TWAR IgG antibody titers are associated with increased risk of CHD.Chronic chlamydia pneumoniae infection may be a risk factor for the developing of CHD.
出处
《中国循环杂志》
CSCD
北大核心
2001年第4期279-281,共3页
Chinese Circulation Journal
基金
卫生部科研基金项目(1998BA1CBB1)
