摘要
目的 :研究乙状结肠镜下直接给药治疗溃疡性结肠炎 (UC)的疗效和安全性。方法 :用随机对照方法对 12 4例溃疡性直肠乙状结肠炎患者分为治疗组 6 4例与对照组 6 0例 ,治疗组给予乙状结肠直视下给药 ,对照组给予局部灌肠治疗 ,疗程 4周。观察临床症状、结肠镜下组织学炎症及疾病活动指数 (DAI)和改善情况。结果 :两种治疗方法症状改善率分别为 87 5 0 %和6 8 33% (P <0 0 5 ) ;结肠镜下炎症改善率分别为 82 81%和 6 5 0 0 % (P <0 0 5 ) ;组织学改善率分别为 85 75 %和 6 1 6 7% (P <0 0 5 ) ;两组的DAI均有明显下降 ,无严重副作用。结论 :乙状结肠镜直视下给药为一有效、简便、安全的治疗溃疡性直肠乙状结肠炎的方法。
Objective To investigate the effect and safety of dr ug used through sigmoidoscope in treatment of ulcerative colitis(UC).Met hod 124 patients with UC were radomly assigned to treatment group giving drugs through sigmoidoscope and contrast group giving enemas.The duration of tre atment was 4 weeks.They were assessed by clinical symptoms,colonscopic finding,t he degree of histological inflammation and Williams disease active index(DAI).Results After the treatment for 4 weeks,the rate of clinical improv ement of treatment group and contrast group was 87 50% and 68 33%,respectively ( P <0 05);the rate of inflammation improvement of treatment group and co ntrast group under sigmoidoscope was 82 81% and 65 00%,respectively( P <0 05);the rate of histological improvement of treatment group and contrast grou p was 85 75% and 61 67%,respectively( P <0 05);In treatment group and c ontrast group,DAI decreased significantly and without serious side effects.Conclusions Drug treatment through sigmoidoscope is a effective,safe a nd convenient therapeutic way for ulcerative colitis.
出处
《吉林医学》
CAS
2001年第4期219-220,共2页
Jilin Medical Journal
