摘要
目的 探讨充血性心力衰竭患者内皮素 (ET -1)、血管紧张素Ⅱ (AngⅡ )及一氧化氮 (NO)的变化及盐酸苯那普利对其影响。方法 采用随机双盲法对 6 0例心力衰竭患者口服盐酸苯那普利 (苯那普利组 30例 )和安慰剂组 (安慰剂组 30例 )治疗 12周。观察治疗前、后的血浆ET - 1、AngⅡ、NO水平及心功能的变化。结果 充血性心力衰竭患者血浆ET - 1、AngⅡ及NO水平较对照组显著升高 (P <0 0 1) ,经盐酸苯那普利治疗后血浆ET - 1、AngⅡ及NO水平明显降低 (P <0 0 1) ,而安慰剂组无明显变化 ,左室射血分数 (LVEF)显著增加 (P <0 0 1)。结论 血浆ET - 1、AngⅡ及NO水平升高是充血性心力衰竭患者重要的病理特征之一。经盐酸苯那普利治疗后 ,充血性心力衰竭患者心功能明显改善 。
Objective To study the effects of benazepril hydrochloride on plasma endothelin 1(ET-1), angiotensin Ⅱ(Ang Ⅱ) and nitric oxide(NO) levels in patients with congestive heart failure(CHF). Methods Sixty Patients with CHF were double blindly randomized into treatment group ( n =30 ) and placebo group ( n =30) , plasma ET-1, Ang Ⅱ and NO concentrations were assessed and normal group 30 as controls. Results Plasma ET-1, Ang Ⅱ and NO levels were higher in patients with CHF than those in normal subjects( P <0 01) and decreased significantly in benazepril hydrochloride group after 12 week treatment, LVEF increased ( P <0 01). No consistent changes were observed in the placebo group. Conclusion CHF is characterized by increased of plasma ET-1, Ang Ⅱ and NO, benazepril hydrochloride can improve heart function of CHF. Benazepril hydrochloride can not only inhibit renin angiotensin aldosteron system but also protect endothelial function.
出处
《岭南心血管病杂志》
2001年第3期172-174,共3页
South China Journal of Cardiovascular Diseases
关键词
盐酸苯那普利
充血性心力衰竭
内皮素
一氧化氮
Benazepril hydrochloride Congestive heart failure Endothelin 1 Nitric oxide
