摘要
目的探讨热休克蛋白 70 ( HSP70 )在慢性乙型肝炎肝组织中的表达及意义。方法采用免疫组化技术对 3 6例慢性乙型肝炎和 2 0例正常肝组织中 HSP70的表达进行检测。结果慢性乙型肝炎和正常肝组织中肝细胞 HSP70表达阳性率分别为 4 5 %和 15 % ,两者相比差异显著 ( χ2 =6.3 ,P<0 .0 5 ) ;中度和重度肝炎 HSP70阳性率明显高于轻度肝炎 (阳性率分别为 62 .5 %和 3 0 % ,χ2 =3 .9,P<0 .0 5 ) ;HSP70阳性细胞多位于灶性和碎屑样坏死区。结论肝细胞 HSP70的异常表达在慢性乙型肝炎免疫保护中起重要作用 ,可作为肝组织损伤的一种标志。
ObjectiveTo investigate the expression and significance of heat shock protein 70(HSP70) in chronic hepatitis B. Methods HSP70 was determined in specimens of 36 cases of chronic hepatitis B and 20 cases of normal liver tissues by immunohistochemistry. Results The positive rate of HSP70 were 45% and 15% in chronic hepatitis and normal liver tissues respectively, there was a significant correlation between them(χ 2=6.3, P<0.05). The positive rate of HSP70 in moderate and severe chronic hepatitis was higher than that in mild chronic hepatitis(62.5% vs 30%,χ 2=3.9, P<0.05). The positive hepatocyte of HSP70 was always found in focal and piecemeal necrosis regions. Conclusion Expression of HSP70 in hepatocytes may play an important role in liver immunological protection, and may be a marker of liver tissue injury in chronic hepatitis B.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2001年第4期292-294,共3页
Immunological Journal
