摘要
目的 探索己酮可可碱 ( PTX)吸入对慢性阻塞性肺疾病 ( COPD)患者血浆内皮素 ( ET- 1)的影响及临床意义。方法 5 1例 COPD患者随机单盲分成治疗组 ( 2 7例 )和对照组 ( 2 4例 ) ,分别给己酮可可碱 ( PTX) 10 0 mg加入生理盐水 5 ml雾化吸入和糜蛋白酶 5 mg加入生理盐水 5 ml雾化吸入。治疗前后检查肺功能、动脉血气、肝肾功能及血浆 IL- 8等。结果 治疗后 ,治疗组 Pa CO2 下降 ,Pa O2 增高 ( P<0 .0 5 ) ;IL- 8、ET- 1明显下降 ( P<0 .0 1)和 ( P<0 .0 5 ) ;FEV1 及 FEV1 有所增高 ,但无统计学意义 ( P>0 .0 5 )。两组治疗前后肝肾功能均无变化。结论 PTX价廉 ,吸入不良反应少 ,不失为临床治疗
Objective To investigate the effects and clinical significance of pentoxifylline(PTX) inhalation on blood plasma ET 1 in patients with Chronic Obstructive Pulmonary Disease(COPD).Method 51 cases COPD patients were randomly divided into two groups:treatment group with inhaled solution and control group without inhaled solution. The solution of PTX (100mg) in 0.9% sodium chloride was used for the treatment group and alfapsin (5mg)in 0.9% sodium chloride for the controls. Before and after the treatment,the paraments of pulmonary function?arterial blood gas analysis?liver and renal function were recorded and blood plasma IL 8 were measured.Results After treatment ,Paco 2 was decreased and Pao 2 increased in the treatment group, (P<0.05);IL 8?ET 1 of plama level were decreased significantly(P<0.01 and P<0.05 respectively);FEV 1 and FEV 1% were higher,but no significant difference was found.(P>0.05)?There was no signticat difference in liver and renal function between the two groups.Conclusion PTX is a cheap,safe drug,especialy by inhalation,It may represent a new method in clinical treatment of COPD.
出处
《临床肺科杂志》
2001年第3期27-28,共2页
Journal of Clinical Pulmonary Medicine
关键词
阻塞性肺疾病
治疗
己酮可可碱
Pulmonary Disease/Obstructive Therapy/pentoxifylline
