摘要
目的 探讨再灌注性心律失常的发生机制。 方法 用家兔制成缺血 -再灌注模型 ,测定缺血 -再灌注心肌的丙二醛含量 ,同时在实验过程中监测心电图。再灌注性心律失常的严重程度用心律失常评分判定。 结果 缺血 -再灌注心肌的丙二醛明显高于对照组 (76 .2 5± 42 .92 vs30 .5 5± 10 .6 5 ,P<0 .0 5 ) ,且与心律失常评分明显正相关 (r=0 .80 8,P<0 .0 1)。 结论 心肌缺血 -再灌注后大量氧自由基产生 。
Objective To study the machanism of reperfusion arrhythmia. Methods Ischemia reperfusion model was made of rabbits.The malondialdehyde(MDA) in the ischemia reperfusion myocardium was tested.In the whole experiment,the EKG was monitored.The severity of the reperfusion arrhythmia was assessed by the arrhythmia score. Results The MDA in the ischemia reperfusion myocardium was significantly higher than the control group.The rise of the MDA was positively related with the arrhythmia score(76 25±42 92vs 30 55±10 65,P<0 05). Conclusion Free oxygen radical was largely produced in the ischemia reperfusion myocardium.It may be one of the causes of the reperfusion arrhythmia
出处
《实用心脑肺血管病杂志》
2001年第2期67-68,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
再灌注性心律失常
氧自由基
丙二醛
病理
Reperfusion arrhythmia Free oxygen radical Malondialdehyde(MDA)
