摘要
目的 :观察羟基喜树碱 (HCPT)为主治疗原发性中晚期肝癌 (HCC)的疗效和毒副作用。方法 :采用HCPT加 5 -氟尿嘧啶 (5 - FU)加 CF联合治疗方案治疗中晚期 HCC 36例 (治疗组 ) ,并与单纯 5 - FU加 CF治疗 HCC13例 (对照组 )进行比较。结果 :治疗组患者临床症状缓解 ,有效率为 72 .2 % (2 2 / 36 ) ,毒副反应发生率低 ,平均生存期为 7.4个月。对照组有效率 6 1.5 % (8/ 13) ,平均生存期为 5 .8个月。结论 :以 HCPT联合化疗方案治疗中晚期HCC,有可能延长患者生存期 ,提高生存质量 ,值得进一步研究。
Objective:To observe the effects and side effects of hydroxycamptothecine (HCPT) in the treatment of advanced hepatic carcinoma.Methods:HCPT+5 FU+CF regimen was compared with 5 FU+CF regimen.Results:36 cases were treated with HCPT+5 FU+CF regimen with a response rate of 72.2%.13 cases were treated with 5 FU+CF regimen with a response rate of 61.5%. The mean survival period were 7.4 months and 5.8 months, respectively.Conclusion:HCPT+5 FU+CF regimen is preferable in the treatment of advaced hepatic carcinoma.It may be improved the quality of life and survival period of patiens.The therapeutic efficacy remains to be studied in the future.
出处
《中国中西医结合消化杂志》
CAS
2001年第3期148-149,共2页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
原发性肝癌
羟基喜树碱
治疗
Hydroxycamptothecine
advanced hepatic carcinoma
curative effects
