摘要
目的和方法 :以大鼠多囊卵巢 (PCO)为动物模型 ,观察了PCO大鼠卵泡颗粒细胞凋亡的发生率 ,并检测了颗粒细胞凋亡时丙二醛 (MDA)的含量及超氧化物歧化酶 (SOD)活性的变化。结果 :①PCO颗粒细胞凋亡发生率明显高于正常 (P <0 .0 0 1) ;②PCO颗粒细胞发生凋亡时 ,细胞内MDA含量增加而SOD活性降低。结论
Aim and Methods: Rat PCO model was established according to the method of Bogovich.Granulosa cells were collected for apoptotic analysis by Tunel method and for mesurement of MDA and SOD.Results:①The percentage of apoptotic granulosa cells of rat PCO was higher than control group( P <0.00l ).②Higher MDA and lower SOD were detected in granulosa cells of rat PCO.Conclusion:The change of MDA and SOD are associated with granulosa cell apoptosis in rat PCO.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2001年第3期293-295,共3页
Chinese Journal of Applied Physiology
关键词
多囊卵巢
颗粒细胞凋亡
丙二醛
超氧化物歧化酶
polycystic ovary(PCO)
granulosa cell apoptosis
malondialdehyde(MDA)
superoxide dismutase(SOD)
