摘要
目的 研究PKCα在人脑胶质瘤细胞中的表达水平及意义。方法 用免疫组化法检测61例胶质瘤标本及4例正常胶质细胞中PKCα的表达水平,分析其表达水平与胶质瘤恶性级别的相关性及意义。结果 在恶性胶质瘤中,PKCα有高表达,但在Ⅱ～Ⅳ级胶质细胞瘤中PKCα表达水平与肿瘤级别呈负相关;在Ⅰ级星形细胞胶质瘤和正常胶质细胞内表达较低。结论PKCα在恶性胶质瘤中具有重要作用,可能与胶质瘤的发生、发展有关。
Objective To investigate the expression levels and implications of PKCα in the patients with gliomas. Methods The expression levels of PKCα were measured by immunohistochemical technique in the 61 cases with gliomas of different malignant degrees as well as in the 4 cases whose gliocytes were normal. The relationship of PKCα expression level to the malignant degree of gliomas and some clinically related factors was analyzed. Results A negative relationship was found between the PKCα expression and the degree of tumor malignancy. In the pilocytic astrocytoma of grade I and in the normal gliocytes, the PKCα expression level was low. The expression level of PKCα was also related to the patient age. Conclusions PKCα may be involved in tumorigenesis and progression of the gliomas.
出处
《中国临床神经外科杂志》
2001年第2期93-94,共2页
Chinese Journal of Clinical Neurosurgery
