摘要
目的 为了减轻糖皮质类固醇激素的副作用，观察了一种新的给药方式─—肾脏脂肪囊内甲基强的松龙注射治疗慢性肾小球肾炎的；临床治疗效果。方法２１例经肾活检证实为原发性肾小球肾炎病人，Ｂ超引导下向每侧肾脂肪囊内注射甲基强的松龙４０ｍｇ，每周２次，共１０次，治疗前后观察病人的尿蛋白、血压、体重及血清白蛋白、肌酐变化。结果对例病人中１８例（８５．１％）病人尿蛋白明显减少或转阴性，未发现明显糖皮质类固醇激素副作用。结论肾囊内注射药物为一新的治疗方法，在有效治疗慢性肾小球肾炎的同时可避免或减少全身给药带来的毒副作用。
Objective To alleviate the side effects of glucocorticoid, we established a new procedure - intra - renal adipose capsule injection therapy to treat chronic glomerulonephritis. Methylprednisolone was injected into human renal adipose capsules of patients to treat primary glomerulonephritis. Methods 21 patients were diagnosed as primary glomerulonephritis by renal biopsies. Under the guide of sonograph,40mg methylprednisolone was injected into each renal adipose capsule of the patients twice a week, and each one of them was totally given ten times of the treatment. The urinary protein,plasma albumin, serum creatinine and blood pressure before and after the treatment were measured. Results The condition of most patients had been improved after the treatments. The excretion of urinary protein in 18 of 21 patients (85.1% ) had significantly been decreased (P < 0. 01 ), and even urinary protein of some patients were negative. We did not find any obvious side effects of glucocorticoid. Conclusions The intra - renal adipose capsule injection therapy is an effective procedure to treat chronic glomerulonephritis with much fewer side effects.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2001年第5期280-281,共2页
Chinese Journal of Practical Internal Medicine
关键词
慢性肾小球肾炎
甲基强的松
柯兴综合征
肾囊内注射疗法
Glomerulonephritis Methylprednisolone Cushing syndrome Intra - renal capsule injection therapy
