摘要
目的 观察甲亢未合并低钾周期性麻痹 (NTHPP)与甲亢低钾周期性麻痹 (THPP)患者血浆血管紧张素 (ATI) ,血管紧张素 (AT )及血清醛固酮 (Ald)水平的变化 ,以探讨 THPP与 AT 、AT 、Ald之间关系。方法 对 73例 Graves病甲亢患者进行了血清钾、2 4小时尿钾、总三碘甲状腺原氨酸 (TT3 )、游离三碘甲腺原氨酸 (FT3 )、总甲状腺素 (TT4)、游离甲状腺素 (FT4)以及卧、立位 AT 、AT 、Ald水平检测 ,其中 THPP患者43例 ,NTHPP患者 30例。结果 THPP组患者血清钾明显低于 NTHPP组患者 (P=0 .0 0 0 ) ,2 4小时尿钾明显高于 NTHPP组 (P=0 .0 0 0 ) ;THPP组患者立位 AT 、Ald水平明显高于 NTHPP组 (P分为 0 .0 0 8,0 .0 13) ,THPP组卧位 AT 、AT 、Ald及立位 AT 较 NTHPP组有升高趋势 ,但差异无显著性 (P>0 .0 5 ) ;2 4小时尿钾、立位AT 、Ald水平与血清钾水平呈负相关关系 ,立位 Ald水平与 2 4小时尿钾水平呈正相关关系。结论 THPP患者AT、Ald水平升高可能是 THPP发病的病因之一 。
Objective To investigate the relationships between the changes of plasma angiotensinⅠ(ATⅠ)?AngiotensinⅡ(ATⅡ). serum aldosterone (Ald) levels and hypokalemic periodic paralysis(THPP) complicating hyperthyroid Graves' disease.Methods The levels of serum potassium, TT 3, TT 4, FT 3, FT 4, Ald and the plasma ATⅠ, ATⅡ and 24 hours urine potassium output were determined in 73 cases of hyperthroid Graves' disease, of which 43 were complicated by THPP and the other 30 were grouped as NTHPP cases. Results The mean level of serum potassium in THPP group was significantly lower than that in NTHPP group( P =0.000), and the mean level of 24 hours urine potassium output in THPP group was significantly higher than that in NTHPP group( P =0.000); The mean levels of plasma ATⅡand serum Ald in THPP group in upright position were significantly higher than those in NTHPP group ( P =0.008 and 0.013,respectively).The mean levels of 24 hours urine potassium output, plasma ATⅡ and serum Ald in upright position were negatively correlated to serum potassium in both groups. The level of serum Ald in upright position was positively correlated to the level of 24 hours urine potassium out put. The mean levels of plasma ATⅠ and ATⅡin supine position were positively correlated to serum T 3, and the level of plasma ATⅡ in upright position was positively correlated to serum FT 3. Conclusion The level of 24 hours urine potassium output rises in THPP patients; the high levels of AT and Ald may contribute to the pathogenesis of the disease .
出处
《华西医科大学学报》
CAS
CSCD
北大核心
2001年第3期435-437,共3页
Journal of West China University of Medical Sciences
