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HLA-Ⅱ类基因与自身免疫性甲状腺疾病 被引量:1

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摘要 自身免疫性甲状腺疾病(AITD)属器官特异性自身免疫性疾病,其发生与遗传因素相关,具有复杂的多基因控制的特点,尤其是人类白细胞抗原(HLA)-Ⅱ类基因及其产物在 AITD发病中有着重要作用。不同人种的研究表明,HLA-Ⅱ类基因位点存在于AITD发病相关的易感基因和保护基因,二者共同作用影响AITD的发生。HLA-Ⅱ类基因的多态性决定HLA-Ⅱ类分子的多样性。本文拟就HLA-Ⅱ类基因及其抗原分子结构、功能以及AITD的易感基因和保护基因的研究进展作一综述。
作者 程昕然
出处 《国外医学(儿科学分册)》 2001年第4期210-213,共4页 Foreign Medical Sciences(Section of Pediatrics)
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