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Th1/Th2免疫应答与婴儿RSV感染 被引量:7

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摘要 呼吸道合胞病毒(RSV)的免疫病理机制尚未完全阐明, RSV感染或刺激后CD4+辅助性T细胞(Th)1/Th2的分化成熟受RSV蛋白抗原种类、呈递形式、细胞因子微环境、宿主主要组织相容性复合体基因等因素的影响,而 Th1/ Th2平衡紊乱、Th2优势免疫应答可能是婴儿RSV毛细支气管炎的发生、发展及预后,尤其是早期喘息和哮喘发生的重要决定因素。对其深入研究,将有助于对RSV免疫病理机制的理解,并可能为其免疫治疗和研制安全、有效的疫苗提供重要的理论依据。
作者 陈志敏
出处 《国外医学(儿科学分册)》 2001年第4期184-187,共4页 Foreign Medical Sciences(Section of Pediatrics)
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