摘要
目的 :研究己酮可可碱 (Pentoxifyline,PTF)对弱精患者精子活力的影响 ,探讨 PTF提高精子活力的作用机理。方法 :采用计算机辅助精子分析 (CASA)系统 ,以同一份精液标本为自身对照 ,测定 PTF处理前后精子活力参数值。结果 :PTF处理后精子活力 (a+b级 )显著提高 (P<0 .0 1) ,对提高快速前向运动精子活力 (a级 )有极显著意义 (P<0 .0 0 5 ) ,而对精子活动率的提高不显著 (P>0 .0 5 ) ;PTF对活动力较好精子活力的提高不及活动力差的明显 (P<0 .0 5 )。结论
OBJECTIVE:To study the effect of pentoxifylline(PTF) on the sperm motility of asthenozoospermic patients and to explore the mechanism to improve the sperm motility.METHODS:We used CASA system to measure the parameters of the sperm motility which was treated with PTF in vitro compared with the untreated controls.RESULTS:The addition of PTF significantly increased the percentage of forwardly progressive spermatozoa(rate a+b) ( P <0.01),especially the percentage of fast forwardly progressive spermatozoa(rate a) ( P <0.005); The improvement of the percentage of non motile spermatozoa was not remarkable(rate d)( P >0.05);The increased rate of sperm motility of poor motile spermatozoa was more obviously than that of well motile spermatozoa( P <0.05).CONCLUSION:PTF can improve the sperm motiltiy of asthenozoospermic patients effectively.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2001年第3期240-242,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
己酮可可碱
弱精
精子活力
Pentoxifylline
Asthenozoospermia
The sperm motility
