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硝苯地平导致药物性牙龈增生的临床研究 被引量:5

Clinical assessment of the relationship between nifedipine and gingival hyperplasia
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摘要 目的 :探讨服用硝本地平与牙龈增生关系和诊断标准。方法 :比较硝苯地平组与非硝苯地平组的 HI、CI、GI、PL I。结果 :对照组牙龈增生发生率为 91.1% ,明显高于硝苯地平组 ,硝苯吡啶组 HI>40 %者为 11/79,明显高于对照组。结论 :不容忽视非硝苯地平引起的牙龈增生 ,硝苯地平可导致牙龈增生 ,但与服药持续时间无相关关系 ;HI>40 %易确诊 ,30 % <HI≤ 40 Objective: To ascertain the relationship between nifedipine and ginigival hyperplasia.Methods:The gingival hypiene indices between nifedipine administered 103 casee(nifedipine group) and non-nifedipine administered168 cases(control group) were compared, HI,CI,GI,PLI were determined and the biopsy of gingival overgrowth was performed. Results:The prevalence of gingival hyperplasia was 91.1% in control group, which was significantly higher than that in nifedipine group. The constituent ratio of HI>40% in nifedipine group was 11179, which was significantly greater than that in control group (p<0.001).Conclusion: The incidence of non-nifedipine induced gingival hyperplasia is very high. but the percentage of nifedipine administered subjects with gingival hyperlasia is greater. nifedipine-induced gingival hyperplasia may be confirmed when HI>40%?Gingival hygiene indices and biopsy are needed for the verification of borderline cases when 30%<HI≤40%.
出处 《广西医学》 CAS 2001年第4期744-745,共2页 Guangxi Medical Journal
关键词 硝苯地平 牙龈增生 药源性疾病 临床研究 nifedipine gingival hyperplasia
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  • 1童月华,实用口腔学(第2版),1991年,254页

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