摘要
目的 :制备盐酸洛美沙星乳膏剂 ,制定其质量控制标准。方法 :采用紫外分光光度法中的对照品比较法测定盐酸洛美沙星乳膏剂中洛美沙星的含量 ,以甲醇为溶剂 ,测定波长 2 87nm。结果 :测得盐酸洛美沙星乳膏剂中洛美沙星平均回收率为 99 80 % ,RSD为 0 2 7% (n =6 ) ,乳剂基质对测定无干扰。结论 :该乳膏剂处方合理 ,制备工艺简单 ,含量测定操作简便 。
OBJECTIVE:To prepare lomefloxacin hydrochloride cream, and establish the quality control standard. METHODS:The content of lomefloxacin hydrochloride was determined with ultraviolet spectrophotometry. The solvent was methyl alcohol,the wavelength of determination was 287nm.RESULTS:The average rate of lomefloxacin hydrochloride was 99.80%,and its RSD was 0.27%( n =6).The base of lomefloxacin hydrochloride cream didn't disturb this determination. CONCLUSION:The technological process of lomefloxacin hydrochloride cream is easy. The method of content determination is simple and accurate.
出处
《药学实践杂志》
CAS
2001年第4期219-221,共3页
Journal of Pharmaceutical Practice
