摘要
目的 :明确抗结核药物副反应的特点。方法 :回顾性分析武汉市结核病医院近十年抗结核治疗过程中发生的需要改变治疗方案的药物副反应发生率。结果 :1492 2例患者中 ,出现需要改变治疗方案的药物副反应 140例 ,占 0 .94% ,其中肝功能损害 6 7例 (47.9% ) ,其次为药物性皮疹 47例 (33.6 % ) ,其它副反应少见。因药物副反应死亡 2例 ,1例由 RFP引起 ,1例未明确为何种药物引起。结论 :抗结核药物副作用引致需要改变治疗方案的副反应中 ,以肝功能损害最多见 ,其次为药物性皮疹。
Objective: To know characteristics of adverse antituberculosis medicament.Methods: Retrospective analysis on adverse reaction leading to changing chemotherapy medicament regimens of anti-tuberculosis in this hospital in recent 10 years. Results: Of 14922 cases, 140 cases stopped chemotherapy regimens because of adverse reaction of anti-tuberculosis medicament incidence rate being 0.94%. Medicamentous liver lesion occurred in 67 cases, dermatitis medicamentosa were in 47 cases, other reactions were few. The death caused by antitubereulosis medicament happened in 2 cases, one being caused by RFP and the other's cause is unknown. Conclusions: Among the adverse reations leading to changing chemotherpy regimens of antituberculosis medicament, the first is liver lesion and the second is dermatitis medicamentosa.
关键词
抗结核药物
副反应
发生率
Anti-tuberculosis medicament Adverse reaction
