摘要
目的 :了解影响茶碱血药浓度的因素以指导临床用药。方法 :对接受茶碱维持量疗法的82 0例患者的茶碱血药浓度监测结果进行了回顾性分析。结果 :35.1%的病例茶碱血药浓度在有效血药浓度范围内 ( 10～ 2 0 μg/ml) ,37.8%的病例茶碱血药浓度低于 10 μg/ml,2 7.1%的病例茶碱血药浓度高于 2 0 μg/ml;环丙沙星、氟罗沙星、沙丁胺醇提高茶碱血药浓度 ,易使茶碱血药浓度偏高 ;特布他林、利福平、速尿降低茶碱血药浓度 ,易使茶碱血药浓度偏低 ;肝功能不正常、肺心病提高茶碱血药浓度 ,易使茶碱血药浓度偏高 ;嗜烟降低茶碱血药浓度 ,易使茶碱血药浓度偏低。结论 :茶碱血药浓度个体差异大 ,药物因素、疾病因素、嗜好等影响茶碱血药浓度 。
Objective:To realize the factors of affecting the serum coneecentration of theophyline.Methods:The data of 820 patients who were monitored by the serum coneentration of theophylline was retrospectively analyzed.Results:35.1% cases were in the range of effective serum concentration of theophylline(10～20μg/ml),37.8% cases were lower than that,and 27.1% cases were higher.Ciprofloxacin,fleroracin and salbutamol increased the serum concentration of theophylline.Terbutaline,rifampicin,and lasix decreased the serum concentration of theophylline.Abnormal liver function and pneumo-cardiopathy increased the serum concentration of theophylline.Being addicted to smoking decreased the serum concentration of theophylline.Conclusion:There was a great individual difference in the serum concentration of theophylline which could be affected by the factors of drugs,disease and hobbies etc.The study indicated that monitoring the serum concentration was important for improving the safety and effectiveness of it.
出处
《赣南医学院学报》
2001年第1期4-7,共4页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
关键词
茶碱
血药浓度
监测
Thephylline:Serum concentration
Monitoring
