摘要
目的 :研究炮制对大黄、虎杖抗氧化作用的影响。方法 :采用体外氧自由基生成系统和羟自由基诱导的小鼠肝匀浆脂质过氧化反应 ,评价炮制对大黄、虎杖抗氧化作用的影响。结果 :大黄、虎杖炮制品均可清除次黄嘌呤 黄嘌呤氧化酶系统所产生超氧阴离子 (O2 ·)以及Fenton反应生成的羟自由基 (·OH) ,并能抑制羟自由基诱导的小鼠肝脏匀浆脂质过氧化 ,各炮制品EC50 之间有一定显著性差异。结论 :炮制降低大黄、虎杖抗氧化能力。
Objective:To investigate the effects of Processing on antioxidation of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati. Method: The oxygen free radicals generation system and mouse liver homogenate lipid peroxidation in vitro were used. Result:The processed products of Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati could scavenge superoxide radical (O 2 · )generated through hypoxanthine oxidase system and (·OH) generated through Fenton action, and inhibit lipid peroxidation induced by hydroxyl radical generation system, respectively. There existed significant differences among the different processed products. Conclusion:After Radix et Rhizoma Rhei and Rhizoma Polygoni Cuspidati were processed, their effects became weaker.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2001年第6期388-391,共4页
China Journal of Chinese Materia Medica
关键词
大黄
虎杖
炮制品
超氧阴离子
羟自由基
脂质过氧化
processing products
Radix et Rhizoma Rhei
Rhizoma Polygoni Cuspidati
superoxide radical
hydroxyl radical
lipid peroxidation
