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Bak基因研究进展

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摘要 Bak基因是从EBV传染的人类B细胞文库中克隆获得的一种基因 ,它可以调节细胞凋亡 ,是Bcl-2家族的一员 ,编码区含有Bcl-2高度同源的BH1、BH2及BH3结构域 ,该区是Bak与Bcl-2、Bcl-xl结合形成二聚体调节细胞凋亡的主要结构基础。
出处 《陕西中医学院学报》 2001年第4期58-60,共3页 Journal of Shaanxi College of Traditional Chinese Medicine
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参考文献10

  • 1Klefer MC,Brauer MJ,Powers VC et al.Modulation of apoptosis by the widely distributed Bcl- 2 homologue Bak[].Nature.1995
  • 2Martoto R,and Perez polo JR.Bcl-2 related protein expression in apoptosis: oxdative stress versus serum deprivation in PC12 cells[].Journal of Neurochemistry.1997
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  • 5Orth K,Dixit VM.Bik and Bak induce apoptoaia downstream of CrmA but upstream of inhibitor of apoptoaia[].Journal of Biological Chemistry.1997
  • 6Monczak Y.Trudel M, Lamph WW et al.Induction of apoptosis without differentiation by retinoic acid in PLB-985 cells requires the activation of both RAR and RXR[].Blood.1997
  • 7Stayrook KR,Mckinzie JH,Burke YD et al.Induction of the apoptosis-promoting protein Bak by perillyl alcohol in pancreatic ductal adenocacinoma relative to untransformed ductal epithelial cells[].Carcinogenesis.1997
  • 8Farrow SN,White JHM,Martinou I et al.Cloning of a bcl-2 hoologue by interaction with adenovirus E1B 19K[].Nature.1995
  • 9Burger N,Nooter K,Boersma AW et al.Lack of correlation between cisplatin-induced apoptosis, p53 status and expression of Bcl-2 family proteins in testicular germ cell tumour cell lines[].International Journal of Cancer.1997
  • 10Hague A,Diaz GD,Hicks DJ et al.Bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells: however overexpression of bcl-2 does not protect against bak-mediated apoptosis[].International Journal of Cancer.1997

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