摘要
选用 5只实验感染肝片吸虫山羊研究 Closantel缓释剂对机体抗氧化功能的影响 ,实验用山羊每只一次性口服肝片吸虫囊蚴 1 50个 ,感染后第 1 5周随机将山羊分成对照组 (n=2 )和驱虫组 (n=3 ) ,驱虫组每羊口服两颗 Closantel缓释剂 ,每周定时采集颈静脉血液 ,检测血清抗氧化酶的变化 ,观察服用 Closantel缓释剂对其的影响。结果表明投药后山羊血清中 GSH- Px、CAT均有不同程度的升高 ,SOD变化不显著 ,而脂质过氧化产物 MDA含量则下降 ,提示 Closantel的缓释剂型对实验感染肝片吸虫山羊机体的抗氧化产生了影响 。
Five goats infected with Fasciola hepatica were chosen to study on the effect of sustained release closantel to anti oxidation function Goats were orally 150 Fasciola hepatica metacercariae once After infected for 15 weeks, goats were random divided into administration(n=3) and control groups(n=2) Goats in administration groups were administrated orally two Closantel sustained release boluses Blood sample from every goat was collected from jugular vein per week Anti oxidant enzyme and nitric oxide in sera were determined in order to observe the effect of closantel sustained release bolus on anti oxidant function and nitric oxide The results showed that GSH Px and CAT activity of administration group increased,While MDA content was decreased after administration It suggests that sustained release closantel has effect on anti oxidation function,thus to prevent the goat.
出处
《中国兽药杂志》
2001年第4期20-23,共4页
Chinese Journal of Veterinary Drug
基金
欧洲联盟资助项目(INCO-DCIC18-CT950001)
