摘要
目的 :探讨长期规律运动对老年大鼠血小板表面Ⅱb/Ⅲa 受体密度的影响。方法 :以老年大鼠为研究对象进行有规律的游泳运动训练 ,90min/次 ,5次 /周 ,共 8周。与成年大鼠进行对照 ,测定运动训练前、运动训练 1周、2周、4周、8周及停止训练后 2周大鼠血小板表面Ⅱb/Ⅲa 受体密度的变化。结果 :老年大鼠运动训练 1周血小板表面Ⅱb/Ⅲa 受体密度增加 ,运动 2周后血小板表面Ⅱb/Ⅲa 受体密度较运动训练前显著降低。结论 :长期规律运动可导致血小板表面Ⅱb/Ⅲa 受体密度降低 ,可能是运动降低老年动物血小板聚集 ,改善血流状态的原因之一。
Objective: To investigate effects of long term exercise training in aged rats on the density of platelet Glycoprotein (GP)Ⅱ b/Ⅲ a receptor . Method: There were 14 aged SD rats and 16 adult SD rats . The platelet surface density of GPⅡ b/Ⅲ a receptors were determined by flow cytometric analysis before and 1,2,4,8 weeks after regular swimming training. Result: 1 week after swimming training ,the density of GPⅡ b/Ⅲ a increased in aged rats ( P <0.05),but no changes in adult rats.2,4,8 weeks after swimming training, the density of GPⅡ b/Ⅲ a decreased continuously both in aged and adult rats.Conclusion: Regular swimming training can lead to a decrease of density of platelet GPⅡ b/Ⅲ a receptor in aged rats .
出处
《中国康复医学杂志》
CAS
CSCD
2001年第3期142-143,共2页
Chinese Journal of Rehabilitation Medicine
