摘要
为探讨 β1 受体阻滞剂比索洛尔对陈旧性心肌梗死 (OMI)患者心功能的影响 ,观察了 35例心功能Ⅱ～Ⅲ级OMI患者在服用比索洛尔 ( 2 .5mg/d)前及用药后 1～ 2月末的心率、血压和多普勒超声参数变化。用药后 ,血压由用药前 ( 2 0 .0 8/ 1 0 .64± 3.33/ 2 .2 6)kPa降至 ( 1 9.4 2 / 1 0 .37± 2 .79/ 1 .86)kPa(P <0 .0 1 ) ,心率由用药前 ( 70 .66±1 2 .86)次 /min降至 ( 64.31± 9.84 )次 /min(P <0 .0 1 ) ,反映左室舒张功能的多普勒超声参数E/A显著增加〔用药前0 .85± 0 .1 8,用药后 1 .1 4± 0 .35(P <0 .0 1 )〕 ,而收缩功能指标每搏输出量 (SV)、心排出量 (CO)、射血分数 (EF)和短轴缩短率 (FS)的变化不明显。因此较小剂量的比索洛尔即可明显降低OMI患者的血压和心率 。
To investigate the effects of bisoprolol on heart function in old myocardial infarction(OMI), 35 patients with OMI received bisoprolol 2.5 mg per day for two months. Doppler echocardiographic measurements of left ventricular structure, transmitral flow velocity pattern, blood pressure and heart rate were monitored before and after 1 and 2 months therapy. Bisoprolol led to reduction in blood pressure and heart rate 〔(20.08/10.64±3.33/2.26) vs (19.42/10.37±2.79/1.86) kPa P <0.01, (70.66±12.86) vs (64.31±9.84) bits/min P <0.01〕, and E/A increased significantly 〔(0.85±0.18) vs (1.14±0.35) P <0.01〕. No significant affection was found on left ventracular systolic function. Bisoprolol reduces blood pressure and heart rate, improves diastolic function, hence it would be valuable in treatment of OMI.
出处
《首都医科大学学报》
CAS
2001年第2期129-131,共3页
Journal of Capital Medical University
