摘要
【目的】证实氟伐他汀对高脂饮食兔血管内皮功能存在早期保护作用。【方法】 40只兔随机等分为治疗组 (高脂饮食 +氟伐他汀 )和对照组 (高脂饮食 )。分别于实验前及实验第 1、2、3、4周每组随机抽取 4只兔 ,取耳中动脉血测血脂水平 ,接着处死 ,分离主动脉 ,进行浴槽试验测定其对血管舒缩药物的反应变化。【结果】实验前对照组和治疗组血管条对硝酸甘油、乙酰胆碱的舒张反应均无差异 ,两组之间比较 ,两组血管条对乙酰胆碱的舒张反应在实验 1周时即出现差异 (P <0 0 5 ) ,但对硝酸甘油的舒张反应至实验 4周时仍然没有差异 (P均 >0 0 5 )。而与实验前比较 ,两组血管条对硝酸甘油的舒张反应至实验 4周时仍然没有差异 (P均 >0 0 5 ) ,对乙酰胆碱的舒张反应在对照组实验 1周时即出现差异 (P <0 0 5 ) ,在治疗组却在实验 2周时才出现差异 (P <0 0 5 )。【结论】胆固醇水平升高导致血管内皮功能受损 ,氟伐他汀不但能防止血脂的上升 。
Objective To prove early protective effect of fluvastatin on vascular endothelial function in rabbits fed by hypercholesterol diet. Methods Forty white rabbits were randomly divided into two groups: control group (Hyperlipid diet: 1% cholesterol, 1.8% lard, 7.5% yolk powder and 83.75% common pellet) and treated group (Hyperlipid diet+fluvastatin 10 mg·kg -1·d -1). Four rabbits were randomly selected from each group before experiment and 1-week, 2-week, 3-week and 4-week after treatment with highlipid diet. The blood samples were drawn in order to measure serum lipids, then the rabbit was killed by air, the aorta was isolated. The aorta was used to test endothelium-dependent and -independent vasodilative response to acetylcholine and nitroglycerine. Results There was no difference in the aortic relaxing response to nitroglycerine and acetylcholine between the two groups before experiment. As time passed, the relaxing response to acetylcholine was shown to be different between the two groups in the first week (P<0.05), but the relaxing response to nitroglycerine kept unchanged in the two groups throughout the studies (P>0.05). The relaxing response to acetylcholine was shown to be different in the first week in the control group as compared to that before experiment (P<0.05), but this difference was found in the second week in the treated group (P<0.05). Conclusion Hypercholesterolemia results in endothelial dysfunction. Fluvastatin not only reduce plasma lipids but also early protect vascular endothelial function in rabbits fed by hypercholesterol diet.
出处
《中山医科大学学报》
CSCD
北大核心
2001年第4期257-260,共4页
Academic Journal of Sun Yat-sen University of Medical Sciences
