摘要
目的：探讨跌打接骨片对实验性骨折愈合的影响。方法：将５６只 ８月龄新西兰大白兔随机分为模型组、跌打接骨片高剂量组、跌打接骨片低剂量组和伤科接骨片对照组 ４组，每组 １４只，所有家兔均行双侧挠骨骨缺损手术。术后第 ２天开始给药，连续用药王术后第 ２２天和 ４２天时处死动物，测定桡骨骨折端的骨组织形态计量学指标。结果：用药２２天时，跌打接骨片高、低剂量组和伤科接骨片组的矿化骨痴面积、骨质面积、活性成骨面％及成骨细胞指数值均大于模型组（Ｐ＜０．０５），而矿化表面积则小于模型组（Ｐ＜０．０５）。用药４２天时，上述３组的成骨细胞活性和矿化延迟时间则分别大于和短于模型组，而其他骨计量动力学参数值则无显著性差异（Ｐ＞０．０５）。结论：跌打接骨片能明显促进家兔骨折愈合。
Objective: To explore the influence of Dieda Jiegu Tablet (DJT) on the healing of experi mental fracture. Methods: Fifty- six New Zealand rabbits aged 8 months were allocated to 4 groups randomly. Group A and Group B were treated with high and low dose of DJT respectively, Group C with Shangke Jiegu Tablet and Group D served as the model control group. The rabbits were medicated in the second day after operation. Histomorphometric indexes of the radius fracture - end were determined after 20 - day treatment and 40 - day treatment respectively. Results: Callus mineraliza tion area, bone area, active osteogenic zone and the osteoblast parameter in Group A, Group B and Group C after 20-day treatment were higher than those in Group D, and mineralization surface area was lower than that in Grousp D. After 40 - day treatment, the activity of osteoblast was still higher and the mineralization rate was lower than those in Group D and no significant differences were found in the other histomorphometric indexes. Conclusion: DJT can accelerate the healing of fracture.
出处
《中药新药与临床药理》
CAS
CSCD
2001年第4期259-262,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广东省中医药管理局课题(编号:97309)
关键词
骨折
中医药疗法
跌打接骨片
骨组织形态计量学
Dieda Jiegu Tablet/pharmacology
Fracture/surgery
@Histomorphometry/Analysis
Rabbits
