摘要
提出了建立在键长涨落模型基础上的蛋白质格点模型 ,通过对二维蛋白质分子的构象研究 ,发现这种蛋白质分子具有更多的紧密接触对、更低的基态能量和更大的平均紧密度 .蛋白质分子的构象数与键数目 N的关系为 :Ω0 ～γN,这里γ=4 .768.
A new protein lattice model basing on the bond fluctuation model is performed in this paper. Through investigation of two dimensional protein structure using our lattice model, we find that our two dimensional protein chains have more contacts. The conformations Ω 0 may be expressed as Ω 0=γ N , here N is chain length and γ =4 768, and the average compactness < ρ(N) > is close to 0 31-0 32 . For the given HP sequences, our protein lattices have lower ground state energies. Comparisons with two dimensional square lattice model are also made.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2001年第7期1241-1243,共3页
Chemical Journal of Chinese Universities
基金
国家自然科学基金 (批准号 :198740 2 1)
国家重点基础研究专项经费 (批准号 :95 -预 -12和 G19990 6 480 0 )
