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新抗癌药安吖啶的药动学

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摘要 本文综述了新抗癌药安吖啶在啮齿类动物和人体内的动态过程及药动学的主要特性,并简述其理化性质和体液中安吖啶浓度的测定方法。本药可以口服,但吸收较差,在体内分布广泛,肝脏内浓度最高,主要以代谢物形式存在;胆汁、肾排泄为重要消除途径;血药-时间曲线为多指数曲线,患者肝肾功能衰竭使生物半衰期延长,清除率减小。
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出处 《国外医学(药学分册)》 1989年第2期74-77,共4页 Foreign Medical Sciences(Section of Pharmarcy)
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  • 1J. W. Paxton,S. E. Foote,R. M. Singh. The effect of buthionine sulphoximine, cimetidine and phenobarbitone on the disposition of amsacrine in the rabbit[J] 1986,Cancer Chemotherapy and Pharmacology(3):208~212
  • 2James W. Paxton,Jeffrey L. Jurlina. Comparison of the pharmacokinetics and protein binding of the anticancer drug, amsacrine and a new analogue, N-5-dimethyl-9-[(2-methoxy-4-methylsulfonylamino)phenyl-amino]-4-acridinecarboxamide in rabbits[J] 1986,Cancer Chemotherapy and Pharmacology(3):253~256
  • 3J. L. Jurlina,A. R. Varcoe,J. W. Paxton. Pharmacokinetics of amsacrine in patients receiving combined chemotherapy for treatment of acute myelogenous leukemia[J] 1985,Cancer Chemotherapy and Pharmacology(1):21~25
  • 4David J. Stewart,Guo Zhengang,Katherine Lu,Niramol Savaraj,Lynn G. Feun,Mario Luna,Robert S. Benjamin,Michael J. Keating,Ti Li Loo. Human tissue distribution of 4′-(9-acridinylamino)-methanesulfon-m-anisidide (NSC 141549, AMSA)[J] 1984,Cancer Chemotherapy and Pharmacology(2):116~119
  • 5A. Emonds,O. Driessen,E. A. Bruijn,A. T. Oosterom. Gas-chromatographic determination of amsacrine (AMSA) in plasma[J] 1981,Fresenius’ Zeitschrift für Analytische Chemie(4):286~287

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