摘要
概述了间隙连接的结构和功能 ,以及pH值、电压、生长因子对它的调节作用 .间隙连接作为相邻细胞间信息物质通道 ,起着传递细胞信息 ,协调细胞群体功能的作用 ,但是其形成过程以及对机体生理功能影响的研究有待进一步深入 .pH值降低可引起间隙连接通道的关闭 ,电压升高降低通道的导电性 ,生长因子可通过影响间隙连接蛋白的形成和降解。
Structure and function of gap junction as well as the role of pH(i), voltage and cytokines on the modulating of gap junction are introduced. Gap junction is an information channel between the adjacent cells, with the function that delivering message and coordinating the actions of cell groups, but its formation and its function on the physical events need more research. The lower pH(i) closes the gap junctional channel and it is explained by 'particle-receptor' model. The increase of voltage downregulates the conductance of the channel. Cytokines; regulate the permeability of gap junction by changing the synthesis and degradation of connexin, enhancing the phosphatizing the connexin.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2001年第4期463-466,共4页
Progress In Biochemistry and Biophysics
