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非典型抗精神病药作用机制的最新学说:快离解学说 被引量：1

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摘要 当初一看到抗精神病药的5羟色胺-多巴胺双受体(5HT_2/D_2)学说,我就觉得不敢苟同。因为氟哌啶醇对精神分裂症的疗效并不坏,但它对5羟色胺受体却没有多少阻滞作用;舒必利是比较专一的多巴胺受体阻滞剂,不作用于5羟色胺受体,也能治好精神分裂症;五氟利多对5羟色胺受体几乎没有什么影响,却能很好地治疗精神分裂症,对有些氯氮平治疗无效的病例,居然也能奏效。看来,‘抗精神病药之所以优越,其原委在于能够作用于5羟色胺和多巴胺两种受体’这种双受体学说,看来并不见得是真理。然而,前一时期,它却成了精神病学界的一股热流。
作者 颜文伟
机构地区 上海市精神卫生中心
出处 《上海精神医学》 北大核心 2001年第2期95-97,共3页 Shanghai Archives of Psychiatry
关键词 抗精神病药 药理 快离解学说
分类号 R96 [医药卫生—药理学]
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参考文献9

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同被引文献34

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上海精神医学
2001年 第2期

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