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细胞凋亡在骨折愈合中的作用 被引量：2

The Effects of Apoptosis during Fracture Healing
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摘要 目的　探讨骨折愈合过程中细胞凋亡的发生及意义。方法　建立颌骨骨折模型 ,利用末端脱氧核苷酸酶(TdT)介导的dUTP X切口末端标记 (TUNEL)法 ,原位观察骨折愈合不同时期细胞凋亡的发生情况。结果　在整个愈合过程中 ,均可见凋亡细胞 ,而膜内骨化期 (第 5d)和软骨形成期 (第 11d)凋亡细胞明显增多。结论　骨折愈合过程伴随凋亡的发生 ,通过凋亡机制控制细胞的数量和清除无用的细胞 。 Objective To elucidate the occurrence and significance of apoptosis during fracture healing of the mandible. Methods An experimental model of fracture was established to detect apoptosis in the different stages of healing by TdT mediated dUTP nick end labeling (TUNEL) method. Results Apoptosis was observed in the whole healing process. The apoptotic cells markedly increased in the stage of intramembranous bone formation (5d) and chondrogenesis (11d). Conclusions Apoptosis is involved in fracture healing. The number of cells was controlled and the useless cells were eliminated by means of apoptosis. This process is helpful to the healing of tissues. [
作者 司晓辉 金岩 杨连甲
机构地区 上海第二医科大学附属第九人民医院口腔医学研究所 陕西西安第四军医大学口腔医学院病理科
出处 《上海口腔医学》 CAS CSCD 2001年第2期132-134,共3页 Shanghai Journal of Stomatology
关键词 凋亡 骨折愈合 TUNEL Apoptosis Fracture Healing TUNEL
分类号 R782.4 [医药卫生—口腔医学]
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参考文献10

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同被引文献30

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引证文献2

二级引证文献11

上海口腔医学
2001年 第2期

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