摘要
本文报道天然黄酮碳苷黑豆素非环类似物的合成.以2,4-二羟基苯乙酮为原料,经酚羟基的单苄基化、Claisen重排、醇醛缩合、I_2/DMSO/浓H_2SO_4关环五步反应得到黄酮;用Claisen重排,分别在黄酮环生成之前和生成之后引入8-位取代基侧链,收率较高.修饰8-位烯丙基侧链,得到了六个黑豆素类似物,其中8的7-位为游离羟基.
Synthesis of acyclic bayin analogues was reported. The substituted flavones were obtained by starting from 2, 4-dihydroxy acetophenone, after monobenzylation, Claisen rearrangement, Aldol condensation and I_2/DMSO/H_2SO_4 cyclization. Claisen rearrangement was used to introduce the 8-substituted side chain before or after the formation of flavone ring with high yield. Allytic side chain was modified to give six bayin analogues in which compoud 8 has a free 7-hydroxy group.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
1991年第6期593-599,共7页
Acta Chimica Sinica
基金
国家自然科学基金资助的项目
