摘要
用化学动力学控制的方法在化合物3的5-C上C=O与6-C发生烯醇化生成锂盐,然后可在6-C位分别引入甲基、烯丙基、苄基、溴以及羟基取代基.产物6、7、8、9a和11经鉴定,除9a外其他都是α和β构型的混合物,其中以α构型取代物为主.
It is known that 11-C-substituted steroids usually possess much higher biological activities than their mother substances. In this paper six 6α-substituted (1S, 7aS)-(+)-1-t-butoxy-7a-methyl-2, 3, 5, 6, 7,7a-hexahydroinden-5-ones(4, 6, 7, 8, 9, 11) were synthesized in good yeilds with high stereoselectivity. These compounds are good intermediates for bhe syntheses of the related 11-C-substituted steroids.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
1991年第4期406-411,共6页
Acta Chimica Sinica
