摘要
目的 探讨活血开窍方治疗急性缺血性中风(AIS)的疗效及药理作用机制。方法 采用随机对照单盲观察法对105例AIS患者进行自由基3项和TXA_2/PGI_2的检测分析，其中中药治疗组69例，尼莫通对照组36例。结果 活血开窍方对AIS的疗效优于尼莫通(P<0.05)，提示活血开窍方能降低患者血浆LPO含量，提高SOD及GSH－Px活性(P<0.01)；抑制TXA_2生成，促进PGI_2合成，使TXA_2/PGI_2比值减小(P<0.01)。结论 活血开窍方能促进自由基清除，减轻自由基损伤，保护脑细胞；能纠正TXA_2/PGI_2失衡，对抗血栓形成，缓解脑缺血。
Objective:To study the effect of the activating circulation prescription on treating Acute Ischemic Stroke(AIS) and its pharmacclogic action mechanism.Methods:Taking random controlled single blind method,105 patients were divided into two groups:activating circulation prescription group (n=69) and nimodipine group (n=36),detecting and analyzing their changing on LPO,SOD,GSH－Px,TXA_2/PGI_2.Results:The effect of activating circulation prescription is dominant to that of nimodipine (P<0.05),and suggests that it can reduce the amount of LPO in plasma,raising that of SOD and the activity of GSH－Px,it can restrain the syntheses of TXA2,and promoting that of PGI_2,dwindling the ratio of TXA_2/PGI_2(P<0.05). Conclusion:The activating circulation prescription can promote to scaveng free radical,reducing free radical injury,protecting cerebrocellular,correcting the imbalance of TXA_2/PGI_2,antagonizing the form of thrombus and reliefing cerebral ischemia.
出处
《中国中医急症》
2001年第3期123-124,共2页
Journal of Emergency in Traditional Chinese Medicine
基金
广东省中医药管理局资助课题(No. 96132)
