微透析技术在癫痫研究中的应用
摘要
微透析技术可用于测量活体细胞外液中各种小分子物质浓度 ,现已广泛应用于脑组织局部代谢研究中。十多年来 ,通过实验及临床研究 ,对于癫痫发作前后能量代谢相关物及氨基酸类神经递质的浓度改变已积累了大量的研究资料 ,极大地推动了对癫痫发作机理的研究 ,并从生化角度为痫灶定位提供了可靠依据。
出处
《国外医学(神经病学.神经外科学分册)》
2001年第3期177-179,共3页
Foreign Medical Sciences(Section On Neurology & Neurosurgery)
参考文献19
-
1During MJ. In vivo neurochemistry of the conscious human brain: intrahippscampal microdialysis in epilepsy. In Robinson TE, Justice JB Jr, eds.Microdialysis in te neurosciences. Amsterdam: Elsevier, 1991 ;425 - 442.
-
2Sherwin AL.Neuroactive amino acids in focally epileptic human brain;a review. Netrochem Res, 1999;24(11): 1387 - 1395.
-
3Ding R, Asada H, Obata K. Changes in extracellular glutamate and GABA levels in the hippocampal CA3 and CA1 areas and the induction of glutamic acid decarboxylase - 67 in dentate granule cells of rats treated with kainic acid. Brain Res, 1998;800(1):105- 113.
-
4Uoda Y, Doi T, Tokumaru J, et al. Kindling phenomena induced by the repeated short- term high potassium stimuli in the ventral lippcampaus of rats: on - line monitoring of extracellular glutamate overflow. Exp Brain Res,2000:135(2): 199 - 203.
-
5Li Z, Yamamoto Y, Morinoto T, et al. The effect of pentylenetetrazolekindling on the extracellular glutamate and taurine levels in the frontal cortex of rats. Neurosci Lett,2000;282(1-2):1i7- 119.
-
6Pont F, Collet A, Lallement G. Early and transient increase of rat hippocampal blood- brain barrier permeability to amino acids during kainic acid - induced seizures. Neurosci Lett, 1995:184( 1 ): 52 - 54.
-
7Bradford HF. Glutamate, GABA and epilepsy. Prog Neurobiol,1995;47(6):477-511.
-
8Meldrum BS. The role of glutamate in epilepsy and other CNS disorders.Neurology,1994;44(11 suppl 8) :s14 - 23
-
9Nakase H,Tada T, Hashimoto H, et al. Experimental study of the mechanism of seizure induction: changes in the concentrations of excitatory amino acids in the epileptic focus of the cat amygdaloid kindling model.Neuro Med Chir(Tokyo), 1994;34(17) :418 - 422.
-
10Liu Z, Stafstrom CE, Sarkisian MR, et al. Seizure - induced glutamate release in magture and immature animals: an in vivo microdialysis study.Neuro report, 1997;8(8) :2019 -2023.
-
1卢军,蒋宇钢,黄红星,曾其昌,王琴,邹叔骋,李波.外科手术治疗难治性癫痫(附99例病例报道)[J].实用预防医学,2009,16(2):497-499. 被引量:3
-
2赵全军,刘宗惠,李士月,刘建杰,田增民,康桂泉,汪允干,朱家瑞,赵文锐,翟又新.单光子发射计算机断层扫描对致痫灶定位价值探讨[J].中华神经外科杂志,1996,12(5):295-298. 被引量:3
-
3杨朋范,王如密,王守森,赵琳,郑兆聪,张小军,荆俊杰,刘峥,张锡增.皮层脑电图监视下手术治疗顽固性癫痫[J].福州总医院学报,2002,9(3):151-152.
-
4马德选,徐如祥,张新伟,柯以铨,周谷兰.偶极子在癫痫外科中对痫灶定位的价值[J].立体定向和功能性神经外科杂志,2000,13(4):191-193. 被引量:3
-
5张新华,樊春红.抑郁症患者血清叶酸和维生素B12浓度研究[J].临床精神医学杂志,2006,16(1):19-20. 被引量:11
-
6刘丛军,曾力,胡威夷.CT、EEG及ECoG痫灶定位36例分析[J].立体定向和功能性神经外科杂志,1991,0(Z1):86-86.
-
7王明芳,张登胜,李家敏,赵军,魏春燕,王冰,魏艳,张莹,李娜,苏继辉.癫痫发作前后血清SOD水平的改变[J].放射免疫学杂志,1997,10(2):75-76.
-
8彭忠兴,周列民,胡月娥.26例癫痫发作时脑电图表现及意义[J].广东药学院学报,2005,21(2):221-222.
-
9吴致勋,孙伯民,田芳镇,马以骝.致痫灶定位及手术治疗的临床研究[J].立体定向和功能性神经外科杂志,1991,0(Z1):17-19. 被引量:2
-
10汤敬一,李飞.近5年针灸治疗血管性痴呆的实验及临床研究进展[J].天津中医药大学学报,2010,29(1):51-53. 被引量:9