摘要
目的研究白芍总苷（ＴＧＰ）对局灶性脑缺血的保护作用。方法大鼠局灶性脑缺血模型采用大脑中动脉阻塞法（ＭＣＡＯ）；脑梗塞区重量用ＮＢＴ染色法测定；９３Ｄ、ＭＤＡ及细胞凋亡均采用测试药盒测定。结果 ＴＧＰ ２０ ｇ·ｋｇ－１ｉｐ可改善大鼠异常神经症状，使ＭＣＡＯ大鼠的ＳＯＤ活力提高、ＭＤＡ生成减少，减少脑皮质细胞凋亡数。结论ＴＧＰ对脑梗塞有保护作用，此作用可能与抗自由基，减少细胞凋亡有关。
AIM To observe the protective effects of TGP on local cerebral ischemia. METHODS The local cerebral ischemia in rat was made by middle cerebral artery occlusion (MCAO). The infraction weight was determined by NBT stain. SOD, MDA and apoptosis were determined with different method respectively. RESULTS TGP 20 mg' kg-1 ip markedly improved the abnormal nervous symptoms, increased the SOD activity and reduced contentes of MDA in MCAO rat. TGP 20 mg.kg- 1 ip significant- ly decreased the nUmbers of apoptotic cells in ischemic cortex. CONCLUSION TGP has protective effects against cerebral infarction, and its mechanism may be related to anti-apoptosis and free radical.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2001年第2期223-225,共3页
Chinese Pharmacological Bulletin
基金
安徽省教委资助课题
No 98JL165
关键词
白芍总苷
大脑中动脉梗塞
超氧化物歧化酶
丙二醛
保护作用
脑缺血
total glucosides of paeony
middle cerebral artery occlusion(MCAO)
superoxide dismutase(SOD)
malondialdehyde (MDA )
apoptosis
