摘要
目的 评价188Re 硫化铼混悬液用于介入治疗肝癌的可能性。方法 30只荷人SMMC 772 1肝癌细胞株的裸鼠肿瘤内分别注射188Re 硫化铼混悬液和188Re NaReO4 溶液 ,进行生物分布研究。另 30只平均分成 6组 ,其中 4组分别注射 0 1mL的 3 7、7 4、18 5、2 9 6MBq的188Re 硫化铼混悬液 ;余下 2组作为对照组注射非放射性硫化铼混悬液和生理盐水。 6d后重复注射。结果 注射188Re 硫化铼混悬液的裸鼠 ,肿瘤内放射性摄取率 (%ID) 1h为 (90 96± 6 6 3) % ,2 4h为 (86 0 9± 2 2 5 8) % ,48h为 (87 6 2± 13 97) % ,高于正常组织。而注射188Re NaReO4 溶液的裸鼠 ,肿瘤内 %ID 1h为 (1 6 6± 0 35 ) % ,2 4h为 (0 0 2± 0 0 1) % ,48h为 (0 0 1± 0 0 1) % ,和正常组织无多大区别。当肿瘤边缘 (距肿瘤中心约 0 5～ 0 6cm)的吸收剂量为 5 0 7 6Gy时 ,肿瘤抑制率可达 89%。结论 188Re
Objective To prepare a [ 188Re] rhenium sulfide suspension and to evaluate its therapeutic effects on liver carcinoma by intratumoral injection Methods 30 unde mice bearing SMMC-7721 human liver carcinoma were used for the biodistribution study after intratumoral injection of [ 188Re] rhenium sulfide suspension or sodium [ 188Re] perrhenate solution Another 30 tumor-bearing nude mice were divided into six groups, four groups of them were treated with a 01mL [ 188Re] rhenium sulfide suspension at doses of 37, 74, 185, 296 MBq by a single intratumoral injection For control studies, the remaining two groups were injected with nonradioactive rhenium sulfide suspension and Hanks' balanced salt solution, respectively Every injection was repeated 6 days later Results The retention percentages of radioactivity (%ID) in tumors injected with [ 188Re] rhenium sulfide suspension were (9096±663)%, (8609±2258)% and (8762±1397)% at 1, 24 and 48 h, respectively, which were much higher than retention in normal organs evaluated In the case of sodium 188Re-perrhenate solution, the %ID values were only (166±035)%, (002±001)% and (001±001)%, respectively Tumor inhibition ratios were as high as 89% when the peripheral portion of tumor (05～06 cm from center) absorbed an activity share of about 5076 Gy Conclusion Intratumoral injection of [ 188Re] rhenium sulfide suspension results in significant tumor restraint and it is indicated that this is a highly potential approach to the treatment of hepatic carcinoma
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2001年第2期99-101,共3页
Chinese Journal of Nuclear Medicine
基金
国家新药研究基金资助项目! (96 90 1 0 5 15 3 )
