摘要
作者在制成以脆弱类杆菌为代表的厌氧菌胆红素结石兔模型基础上,对脆弱类杆菌与大肠杆菌在成石中的作用进行了对比研究。作者证实脆弱类杆菌与大肠杆菌按最适比例导致的胆道感染形成的结石最多。早期控制感染是防止成石的关键。脆弱类杆菌产生β-葡萄糖醛酸酶的能力较大肠杆菌强,在色素石成石中作用更大。
A comparative study ofBacteroides fragilis and E.coli bacterial in-fection in the biliary tract in relation tothe pathogenesis of pigment stone forma-tion was carried out on the basis of galls-tone rabbit's model of anaerobic bacterialinfection. One hundred and twenty Japa-nese hybrid big-ear white rabbits wererandomly divided into four groups:14 incontrol group,31 in B.fragilis(BF)group, 42 in E.coli group and 33 in the mixed group.In the experimental groups we success-fully made gallstone formation in aerobic,anaerobic and mixed bacterial infectionsin biliary tracts respectively. On 7,15 and30 postoperative days the survival rabbitswere sacrificed for investigations. Our ex-periments demonstrated that the incidenceand amount of stone formation in the mi-xed group were the highest among the ex-periment gronps. The key point to preclu-de stone formation was to control the bac-terial infection in the biliary tract as earlyas possible. The results suggested that theability of production of β-glucuronidasein BF group was significantly higher thanthat in E.coli group. The author consideredthat BF was more important than E.coli inthe pathogenesis of calcium bilirubinategallstone formation.
出处
《华西医科大学学报》
CSCD
1991年第4期416-419,共4页
Journal of West China University of Medical Sciences
关键词
厌氧菌
胆红素结石
结石
胆道感染
Bacteroides fraglis
Calcium bilirubinate gallstone
Biliary tract infection β-glucuronidase
