摘要
本文报导了黄芪多糖（ＡＰＳ）的抗肿瘤实验研究。体内实验结果表明：肌注ＡＰＳ２．５ｍｇ／Ｋｇ、５ｍｇ／Ｋｇ、１０ｍｇ／Ｋｇ、２０ｍｇ／Ｋｇ四个剂量对小鼠移植性肿瘤Ｓ１８０、肝癌（Ｈｅｐｓ）均有明显的抑制作用。体外试验结果表明：黄芪多糖与白介素２（ｒＩＬ－２）配伍应用可以明显提高ＬＡＫ细胞对靶细胞Ｐ８１５和Ｙａｃ－１细胞的杀伤率。结合其它免疫功能指标观察，提示黄芪多糖抗肿瘤效应可能主要与黄芪多糖具有增加机体免疫功能的作用有关。
his paper reports the experimental study on antineoplastic activity of astragalus
polysaccharide(APS) . The tests in vivo indicate that : intramuscular injection of four doses of
APS 2. smg/kg,smg/kg, 10mg/kg 20mg/kg has the obvious inhibition of both transplantiry
tumour S-180 and livercancer (Hepe) in mice. The tests in vitro indicate that: Combined
administrat-ion of astragaluspolysaccharide and interleukin-2 (rlL-2) can enhance apparently
the killing rate of LAK cells againstthe target cells P-815and Yac-1; According to the other
immunololgical function index, it is pointed outthat the antineoplastic effect of astragalus
polysaccharide may be mainly related to its action to strength-ening the or bedy's
immuniological function.
出处
《药物生物技术》
CAS
CSCD
1995年第2期22-25,共4页
Pharmaceutical Biotechnology
关键词
黄芪多糖
抑瘤率
免疫功能
实验
Astragalus polysaccharide
Tumour inhibition rate
immunologieal function.
