摘要
目的探讨低剂量结合型雌激素（ＣＥ）和安宫黄体酮（ＭＰＡ）联合应用，对绝经后妇女骨代谢的影响。方法３４例绝经后妇女，随机分为２组：试验组１７例，ＣＥ０．６２５ｍｇ与ＭＰＡ２ｍｇ隔日口服，交替应用；对照组１７例，每天口服ＣＥ０．６２５ｍｇ，每月连续服用２５天，后１０天加用ＭＰＡ４ｍｇ。两组均连续服用４周期，于服药前后分别测定血碱性磷酸酶（ＡＬＰ）及尿Ｃａ／Ｃｒ比值。结果治疗后两组ＡＬＰ均无明显变化（Ｐ＞０．０５），尿Ｃａ／Ｃｒ均明显下降（Ｐ＜０．０５，Ｐ＜０．０１），两组治疗效果无明显差异（Ｐ＞０．０５）。结论绝经后妇女低剂量激素替代治疗对骨形成无作用，可抑制骨吸收。
Objective To study the effects of low dose hormonal replacement therapy(HRT) on the bone metabolism in postmenopausal women(PMW). Methods 34 cases of postmenopausal women were randomly divided into trial group (17 cases) and control group(17 cases). The trial group received low dose estrogen and progestogen:conjugated estrogen(CE) 0 625 mg and medroxyprogesterone acetate(MPA) 2 mg qod alternately. The control gruop was treated with CE 0 625 mg daily for 25 days in combination with cyclic MPA 4 mg daily, the last 10 days for 4 cycles. Fasting urinary Ca/Cr and serum alkaline phosphatase(ALP) concentration were measured before and after treatment in all subjects. Results The results showed that in both groups, the fasting urinary Ca/Cr ratio reduced significantly ( P<0 05), while serum ALP showed no significant change after treatment. The change of the parameters was not significant between the 2 groups ( P >0 05). Conclusion The low dose hormonal replacement therapy could effectively reduce the bone absorption and prevent osteoporosis.
出处
《临床骨科杂志》
1998年第1期30-31,共2页
Journal of Clinical Orthopaedics
关键词
骨质疏松
绝经后
激素替代治疗
骨代谢
雌激素类
孕酮
osteoporosis, postmenopausal
hormonal replacement therapy
bone metabolism
estrogen
progesterone
