摘要
用结扎家免左冠状动脉建立急性心肌梗死区的模型,探讨梗死区心肌中K^+/Na^+、Mg^(2+)/Ca/^(2+)、Zn^(2+)/Cu^(2+)比值的变化与急性心肌梗死发生时间的规律。结果提示:(1)K^+/Na^+、Mg^(2+)/Ca/^(2+)比值随心肌缺血时间延长呈进行性下降。K^+/Na^+比值在60min、120min实验组与对照组比较有显著性差异(P<0.01);(2)Zn^(2+)/Cu^(2+)比值各实验组与对照组比较无显著性差异(P>0.05),但实验组随缺血时间延长,Zn^(2+)/Cu^(2+)比值呈下降趋势,120min组比15min、30min、60min组降低约1/2(PC<0.01)。测定心肌梗死区K^+/Na^+、Mg^(2+)/Ca/^(2+)比值可以作为显示和判定急性心肌梗死的重要指标。
Using the animal model of acute myocardial infarction of rabbit after left coronary artery ligation, the authors studied the reltionship between the change of myocardial K^+/Na^+ ,Mg^(2+)/Ca^(2+), and Zn^(2+)/Cu^(2+) ratio and the time after acute myocardial infarction. The results demonstrated that. (1)the K+/Na^+ and Mg^(2+)/Ca^(2+)ratio dropped with prolongation of time myocardial ischemia. There was significant (P<0.01)difference of K^+/Na^+ratio between the experimental group and the control group at 60 min and 120 min of myocardial isehemia. The difference of Mg^(2+)/Ca^(2+) ratio was significant between its experimental group and contral group (P<0.01). (2)There was no significant (P>0.05)difference of Zn^(2+)/Cu^(2+) ratio between the experimental groups and the control group, but Zn^(2+)/Cu^(2+) ratio showed a tendency of dropping with prolongation of time of ischemia in the experimental group. At 120 min of myocardial ischemia,the Zn^(2+)/Cu^(2+) ratio was abour 1/2 as those at 15min, 30min, and 60min(P<0.01). It was suggested the K^+/Na^+ and Mg^(2+)/Ca^(2+) ratio of myocardial infarction area were the important criterion of diagnosis of acute myocardial infarction.
出处
《中国法医学杂志》
CSCD
1993年第3期143-144,共2页
Chinese Journal of Forensic Medicine
基金
河南省教委自然科学基金
