摘要
目的 :探讨小剂量尿激酶多次静滴治疗顽固性心绞痛的临床效果。方法 :对 70例经积极的抗缺血和抗血栓治疗 5～ 7d效果不佳的顽固性心绞痛患者 ,随机分为两组。对照组 35例 ,继续应用硝酸醋类、β受体阻滞剂、钙拮抗剂、阿斯匹林及低分子肝素治疗 ;治疗组 35例 ,在上述治疗的基础上 ,用小剂量尿激酶 3×1 0 5u加入生理盐水 1 0 0 ml静滴 ,半小时内滴完 ,每日 1次 ,共 3d。结果 :治疗组的总有效率明显高于对照组(P<0 .0 1 ) ,其急性心梗或猝死的发生率低于对照组 ,无严重的出血。结论 :该疗法安全、有效 ,可改善近期预后。
Objective:To investigate the clinical effect of small dose Urokinase(UK) in intractable angina pectoris(IAP).Methods:All 70 IAP patients who had proved ineflective after 5 7 days of anti ischemic and anti thrombotic therapy were randomly divided into two groups:35 patients(control group) were treated with nitric acid ester,β receptor blocking agent,Calcium antagonist,aspirin and low molecular heparin;in addition to the above treatment,another 35 patients(UK group) were given intravenous drip of UK 3×10 5u in 100 ml normal saline one every, half an hour every day for 3 days.Results:Total effective rate of the UK group was evidently higher than that of the control grup( P <0 01).The incidence of acute heart attack and sudden death of the UK group was lower,with no serious hemorrhage.Conclusion:Small dose of UK is effective and safe for the treatment of IAP.It can improve immediate prognosis.
出处
《滨州医学院学报》
2001年第3期221-222,共2页
Journal of Binzhou Medical University
关键词
尿激酶
顽固性心绞痛
溶栓
治疗
urokinase
intractable angina pectoris
embolism dissolution
