摘要
[目的]探讨恶性周围神经鞘膜瘤镜下形态特点 ,确立鉴别诊断思路。[方法]24例恶性周围神经鞘膜瘤经常规检查及免疫标记证实 ,观察其HE切片镜下形态。[结果]恶性周围神经鞘膜瘤根据形态可分为普通型17例(71 %)和特殊型7例(29%)。S_100为该瘤最敏感的标记物 ,髓磷脂碱性蛋白为最可靠的标记物。[结论]恶性周围神经鞘膜瘤组织形态多样 ,变异甚大 ,常易错诊为其它肿瘤 ,免疫标记对确立正确的诊断思路有较大帮助。
To investigate the light microscopic manifestation in malignant peripheral nerve sheath tumors (MPNSTs) and provide a way of thinking for differential diagnosis. Twenty four cases of MPNSTs were studied by routine stain and proved with immunohistochemistry and its morphological characters were analysed by light microscopy.According to morphological characters,MPNSTs were classified as follows:general type:17 cases(71%),special type:7cases(29%).S 100 is the most sensitve marker of MPNST and myelin basic protein (MBP) is the most reliable marker.[Conclusions]Morphological characters of MPNSTs are various.They are easy to misdiagnosis as other tumors.Immunohistochemistry is playing an important role in the accurate diagnosis.
出处
《肿瘤学杂志》
CAS
2001年第1期41-42,共2页
Journal of Chinese Oncology
关键词
恶性周围神经鞘膜瘤
形态特征
病理学
诊断
免疫组化
malignant peripheral nerve sheath tumor
morphological characters
pathology,clinical
diagnosis,differential
immunohistochemistry
