摘要
目的 研究轻度高温、亚低温对局灶脑缺血 EAA和 IAA的影响。方法 建立大鼠可复流 MCA闭塞模型 ,诱导目标脑温 ,用 HPL C荧光法检测脑组织 Glu、Asp、Gly、GABA含量。结果 轻度高温组 Glu、Asp、Gly明显增高 ,GABA短暂增高后下降 ;亚低温组 Glu、Asp、Gly降低 ,GABA持续增高。结论 轻度高温促进 [Glu]×[Gly]/ [GABA]比值增加 ,在持续增加 Glu“兴奋毒性”方面起重要作用 ;亚低温使 [Glu]× [Gly]/ [GABA]比值下降 ,在降低 Glu“兴奋毒性”方面起重要作用。轻度高温不利于 ;亚低温有利于“抑制性保护”
Objective To research the effects of mild hyperthermia and mild hypothermia on excitatory amino acid(EAA) and inhibitory amino acid(IAA) respectively.Methods Test the concentration of glutamate(Glu),aspartate(Asp),glycine(Gly) and GABA respectively by using HPLC after establishing of model of reflowable cerebral middle artery occlusion of rats and inducing target brain temperature.Results The concentration of Glu,Asp,Gly increased markedly, and that of GABA increased significantly and temporarily, Then decreased rapidly in mild hyperthermia group, The concentration of Glu,Asp,Gly decreases significantly and that of GABA increased markedly and continuously in mild hypothermia group.Conclusions Mild hyperthermia increases the value of ratio of [Glu]×[Gly]/[GABA] and plays an important role in continuously increasing excitatory toxicity of Glu, mild hypothermia decreases the value of ratio of [Glu]×[Gly]/[GABA] and serves as a significant part in reducing excitatory toxicity of Glu.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2001年第2期78-80,共3页
Journal of Apoplexy and Nervous Diseases
关键词
脑缺血
氨基酸递质
高温
亚低温
抑制性保护
再灌注损伤
Focal cerebral ischemia
Amino acid neurotransmitter
Mild hyperthermia
Mild hypothermia
Inhibitory protection
