摘要
脑受体的PET显像剂制备研究具有重要意义 ,其中以18F标记的药物研究最多。介绍了18F标记的脑受体PET显像剂制备的一般方法 ,对亲核取代法进行了较为详细的讨论 ,分析了主要影响因素 ;按照脑受体功能进行分类 ,回顾了近年来脑受体的PET显像剂制备研究的一些进展。
It is of great importance to study the preparation of radiopharmaceuticals for brain receptor imaging with PET, among which Fluorine-18 was used as the radionuclide in many of these radiopharmaceuticals. This paper reviews the common methods for preparing Fluorine-18 labelled radiopharmaceuticals for brain receptor imaging, with particular emphasis on nucleophilic routes. Some progresses on the preparations of the radiopharmaceuticals classified according to the corresponding receptors were also discussed.
出处
《核技术》
CAS
CSCD
北大核心
2001年第5期428-432,共5页
Nuclear Techniques
