摘要
目的 探讨6－氨基己酸在二尖瓣替换术中减少出血的作用。方法 1997年6月－1999年3月选择50例成人二尖瓣替换患者，按随机双盲法分为两组，每组25例。治疗组在切皮之前静脉注射6－氨基己酸10g，对照组给予等量的生理盐水，记录每例在给药后ACT、关胸期、术后6h、术后24h胸部及纵隔失血量等进行组间比较。结果 治疗组和组术手6h及24h胸部失血量分别为：（290.0±41.3）ml和（393.4±73.6）ml及（336.3±81.3)ml和(450.0±79.6)ml，两者相比，P<0.05，均有显著差异。结论 6－氨基己酸可减少二尖瓣替换术后失血。
Objective\ To determine the effect of 6-aminocaproic acid (EACA) to reduce postoperation bleeding following in mitral valve replacement.Method\ 50 adult patients uddergoing mitral valve replacement was adopted a double-bisind randomized trial to be divided into two groups.Each group is 25 patients.The patients in control groups received NS,the ones in study groups received NS as same as control groups but added EACE 10 g by intravation.The bleeding amount in cavitas thoracis were recorded on the sixth,twenty-fourth postoperative hours and ACT was recorded as well.Results\ The bleeding amount in study groups on the sixth postoperative hours were (290.0±41.3) ml.On twenty-fourth postoperative hours were (336.3±81.3) ml.The bleeding amount in control groups on the sixth postoperative hours were (393.4±73.6) ml.On twenty-fourth postoperative hours were (450.0±79.6) ml.The bleeding amount in study groups were decreased significantly as compared with in control groups (P<0.05).Conclusion:6-aminocaproic acid can reduce postoperation bleeding following in mitral valve replacement.
出处
《医师进修杂志》
北大核心
2001年第5期20-21,共2页
Journal of Postgraduates of Medicine
